diff --git a/transport/src/main/java/io/netty/channel/AbstractChannel.java b/transport/src/main/java/io/netty/channel/AbstractChannel.java
index fd00947d22..fa66d0907f 100644
--- a/transport/src/main/java/io/netty/channel/AbstractChannel.java
+++ b/transport/src/main/java/io/netty/channel/AbstractChannel.java
@@ -442,8 +442,16 @@ public abstract class AbstractChannel extends DefaultAttributeMap implements Cha
                 pipeline.fireChannelRegistered();
                 // Only fire a channelActive if the channel has never been registered. This prevents firing
                 // multiple channel actives if the channel is deregistered and re-registered.
-                if (firstRegistration && isActive()) {
-                    pipeline.fireChannelActive();
+                if (isActive()) {
+                    if (firstRegistration) {
+                        pipeline.fireChannelActive();
+                    } else if (config().isAutoRead()) {
+                        // This channel was registered before and autoRead() is set. This means we need to begin read
+                        // again so that we process inbound data.
+                        //
+                        // See https://github.com/netty/netty/issues/4805
+                        beginRead();
+                    }
                 }
             } catch (Throwable t) {
                 // Close the channel directly to avoid FD leak.
diff --git a/transport/src/test/java/io/netty/channel/nio/NioSocketChannelTest.java b/transport/src/test/java/io/netty/channel/nio/NioSocketChannelTest.java
index 3d5b47dfd4..fc75dda475 100644
--- a/transport/src/test/java/io/netty/channel/nio/NioSocketChannelTest.java
+++ b/transport/src/test/java/io/netty/channel/nio/NioSocketChannelTest.java
@@ -15,16 +15,26 @@
  */
 package io.netty.channel.nio;
 
+import io.netty.bootstrap.Bootstrap;
 import io.netty.bootstrap.ServerBootstrap;
+import io.netty.buffer.ByteBuf;
 import io.netty.buffer.Unpooled;
+import io.netty.channel.Channel;
 import io.netty.channel.ChannelFuture;
 import io.netty.channel.ChannelFutureListener;
 import io.netty.channel.ChannelHandlerContext;
 import io.netty.channel.ChannelInboundHandlerAdapter;
+import io.netty.channel.ChannelInitializer;
 import io.netty.channel.ChannelOption;
+import io.netty.channel.ChannelPipeline;
+import io.netty.channel.EventLoop;
+import io.netty.channel.EventLoopGroup;
+import io.netty.channel.SimpleChannelInboundHandler;
 import io.netty.channel.socket.nio.NioServerSocketChannel;
+import io.netty.channel.socket.nio.NioSocketChannel;
 import io.netty.util.CharsetUtil;
 import io.netty.util.NetUtil;
+import io.netty.util.internal.ThreadLocalRandom;
 import org.junit.Test;
 
 import java.io.DataInput;
@@ -35,6 +45,7 @@ import java.net.Socket;
 import java.net.SocketAddress;
 import java.nio.channels.ClosedChannelException;
 import java.util.Queue;
+import java.util.concurrent.CountDownLatch;
 import java.util.concurrent.LinkedBlockingQueue;
 
 import static org.hamcrest.CoreMatchers.*;
@@ -141,4 +152,92 @@ public class NioSocketChannelTest {
             group.shutdownGracefully().sync();
         }
     }
+
+    // Test for https://github.com/netty/netty/issues/4805
+    @Test(timeout = 3000)
+    public void testChannelReRegisterReadSameEventLoop() throws Exception {
+        testChannelReRegisterRead(true);
+    }
+
+    @Test(timeout = 3000)
+    public void testChannelReRegisterReadDifferentEventLoop() throws Exception {
+        testChannelReRegisterRead(false);
+    }
+
+    private static void testChannelReRegisterRead(final boolean sameEventLoop) throws Exception {
+        final EventLoopGroup group = new NioEventLoopGroup(2);
+        final CountDownLatch latch = new CountDownLatch(1);
+
+        // Just some random bytes
+        byte[] bytes = new byte[1024];
+        ThreadLocalRandom.current().nextBytes(bytes);
+
+        Channel sc = null;
+        Channel cc = null;
+        ServerBootstrap b = new ServerBootstrap();
+        try {
+            b.group(group)
+             .channel(NioServerSocketChannel.class)
+             .childOption(ChannelOption.SO_KEEPALIVE, true)
+             .childHandler(new ChannelInitializer<Channel>() {
+                 @Override
+                 protected void initChannel(Channel ch) throws Exception {
+                     ChannelPipeline pipeline = ch.pipeline();
+                     pipeline.addLast(new SimpleChannelInboundHandler<ByteBuf>() {
+                         @Override
+                         protected void channelRead0(ChannelHandlerContext ctx, ByteBuf byteBuf) {
+                             // We was able to read something from the Channel after reregister.
+                             latch.countDown();
+                         }
+
+                         @Override
+                         public void channelActive(final ChannelHandlerContext ctx) throws Exception {
+                             final EventLoop loop = group.next();
+                             if (sameEventLoop) {
+                                 deregister(ctx, loop);
+                             } else {
+                                 loop.execute(new Runnable() {
+                                     @Override
+                                     public void run() {
+                                         deregister(ctx, loop);
+                                     }
+                                 });
+                             }
+                         }
+
+                         private void deregister(ChannelHandlerContext ctx, final EventLoop loop) {
+                             // As soon as the channel becomes active re-register it to another
+                             // EventLoop. After this is done we should still receive the data that
+                             // was written to the channel.
+                             ctx.deregister().addListener(new ChannelFutureListener() {
+                                 @Override
+                                 public void operationComplete(ChannelFuture cf) {
+                                     Channel channel = cf.channel();
+                                     assertNotSame(loop, channel.eventLoop());
+                                     group.next().register(channel);
+                                 }
+                             });
+                         }
+                     });
+                 }
+             });
+
+            sc = b.bind(0).syncUninterruptibly().channel();
+
+            Bootstrap bootstrap = new Bootstrap();
+            bootstrap.group(group).channel(NioSocketChannel.class);
+            bootstrap.handler(new ChannelInboundHandlerAdapter());
+            cc = bootstrap.connect(sc.localAddress()).syncUninterruptibly().channel();
+            cc.writeAndFlush(Unpooled.wrappedBuffer(bytes)).syncUninterruptibly();
+            latch.await();
+        } finally {
+            if (cc != null) {
+                cc.close();
+            }
+            if (sc != null) {
+                sc.close();
+            }
+            group.shutdownGracefully();
+        }
+    }
 }